3810 – GliaDea IgG
Intended Use
The GliaDea IgG is a quantitative immunoassay for the determination of IgG antibodies against deamidated gliadin in human serum. The GliaDea IgG is intended as an aid in the diagnosis of celiac disease in conjunction with other clinical and laboratory findings. The immunoassay is designed for manual professional in vitro diagnostic use.
Diagnostic Relevance
Celiac disease or gluten-sensitivity is characterized by small intestinal damages leading to a so-called “flat” mucosa. Due to this extensive lesions, malabsorption occurs frequently accompanied with a depletion of key nutrients. The alcohol soluble fraction of gluten, gliadin, a substrate of tissue transglutaminase (tTG), represents a causative agent of celiac disease, by stimulating an inflammatory process in the small intestine. Cellular and humoral immune responses are probably triggered by the cross linking of gliadin into high molecular complexes.
Serological method of celiac disease diagnosis includes the detection of IgA and IgG antibodies to tissue transglutaminase and deamidated gliadin. IgA antibodies to tissue transglutaminase are considered to have the highest predictive value, thus patients suffering from IgA deficiency, a frequent concomitant disease in celiac patients, can be diagnosed using IgG type antibodies.
Product Specifications
Title | GliaDea IgG |
Product code | 3810 |
Indication | Celiac disease |
Description | Enzyme immunoassay for the quantitative determination of IgG antibodies against deamidated gliadin in human serum |
Format | Microtiter plate coated with deamidated gliadin |
Total incubation time | 105 min. |
Sample volume | 10 µL serum |
No. of determinations | 96 (89 x 1) + 5 x Calibrators and 2 x Controls |
Free downloads
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Current version of the instructions for use. The respective valid version for processing the test can be found in the product packaging.