In regions affected by recurrent cholera outbreaks, overlapping infectious diseases can obscure the diagnosis of post-infectious autoimmune conditions. We recently collaborated in the publication describing a pediatric case from Yemen that illustrates how Guillain–Barré Syndrome (GBS) can emerge during a cholera outbreak, highlighting the critical role of Campylobacter jejuni infection and anti-ganglioside antibody testing 1. […]

Inflammatory bowel diseases (IBD), which include Crohn’s disease (CD) and ulcerative colitis (UC), are chronic disorders driven by immune dysregulation, environmental triggers, genetic predisposition, and alterations in the gut microbiota. Growing evidence highlights the role of serological biomarkers in IBD in improving disease characterization, early diagnostic refinement, and patient stratification. A new large-scale prospective investigation […]

Understanding Anti-GAD65 Antibodies and Their Clinical Significance Anti-glutamic acid decarboxylase antibodies (anti-GAD65) are among the most important biomarkers in autoimmune diseases. They play a dual diagnostic role: These antibodies can reach concentrations 100–500 times higher in neurological disease compared with diabetes, making quantitative accuracy crucial. A recently published scientific study evaluated the clinical performance of […]

A German Pilot Study Using AI-Assisted Interpretation of ANA Artificial intelligence is rapidly transforming medical diagnostics—from radiology to immunology. Now, a new German pilot study reveals how AI-assisted interpretation of ANA tests could lead to faster, more consistent, and more reliable diagnosis of autoimmune diseases. With this study, the University Medical Center Regensburg and Asklepios […]

Anti-neutrophil cytoplasmic antibodies (ANCA) Anti-neutrophil cytoplasmic antibodies (ANCA) are key biomarkers in the diagnosis of ANCA-associated vasculitis (AAV), a group of rare but potentially life-threatening autoimmune diseases. They can also have clinical and diagnostic value in certain non-AAV conditions. Early and accurate detection of ANCA is critical for initiating treatment promptly and improving long-term outcomes. […]

We are pleased to share the results of a newly published peer-reviewed study in Scientific Reports that demonstrates the diagnostic performance of the CytoBead® ANA 2 assay1. In clinical diagnostics, the detection of antinuclear antibodies (ANA) is crucial in identifying systemic autoimmune rheumatic diseases (SARDs). Traditional diagnostics use a two-step process. First, ANA screening by […]

Type 1 diabetes management has long relied on insulin injections, carbohydrate counting, and vigilant blood sugar monitoring. But how will the landscape in the near future look like? According to prominent German pediatric endocrinologist Felix Reschke (Kinder- und Jugendkrankenhaus in Hannover), the next five years could redefine treatment strategies entirely – he said in an […]

June is recognized as Scleroderma Awareness Month to honor those affected by the disease. The month ends with World Scleroderma Day on June 29. This date commemorates Swiss painter Paul Klee, who died of systemic sclerosis in 19401. Scleroderma, or systemic sclerosis, is a rare autoimmune disease. It causes hardening and tightening of the skin […]

Celiac disease (CD) diagnosis has advanced significantly over the past decade. Global guidelines now emphasize a combination of serology, genetics, and histology. While regional approaches differ, all aim for accurate diagnosis with minimal invasiveness. Core serological markers include antibodies against tissue transglutaminase (tTG), deamidated gliadin peptide (DG), and endomysial antibodies (EmA), assessed in both IgA […]

Antiphospholipid Syndrome (APS) is a major risk factor for pregnancy complications, yet diagnosing it remains challenging. Recent advancements in APS diagnostics provide deeper insights into its role in recurrent pregnancy loss and preeclampsia. Cutting-edge biomarker research and refined testing methods are improving accuracy, helping clinicians better identify at-risk patients and tailor treatment strategies. Discover the latest developments in APS diagnostics and their impact on maternal and fetal health.