8049 – Anti-MuSK IFA

Intended Purpose

The Anti-MuSK IFA is an immunofluorescence assay (IFA) for the qualitative and semi-quantitative determination of IgG antibodies in human serum against muscle specific tyrosine kinase (MuSK) on HEp-2 cells. The Anti-MuSK IFA is intended as an aid in the diagnosis of myasthenia gravis (MG) in conjunction with other clinical and laboratory findings. The immunoassay is designed for manual professional in vitro diagnostic use.


Diagnostic Relevance

Myasthenia gravis (MG), a neurological disease characterized by disturbed signal transmission between nerves and muscles, is an autoimmune disease, caused by autoantibodies directed against the striated muscle of the motor end plate. In most cases (ca 85%), acetylcholine receptor antibodies are detectable. Antibodies against muscle specific tyrosine kinase (MuSK) are also detectable in 1 – 10% of cases. In other cases, the so-called low affinity acetylcholine-receptor-antibodies or antibodies against the lipoprotein receptor-related protein (LRP4) are seen.

Product Specifications

Title Anti-MuSK IFA
Product code 8049
Indication Myasthenia gravis
Description Indirect immunofluorescence assay for the determination of IgG antibodies in human serum against muscle specific tyrosine kinase
Format Slides coated with transfected HEp-2 MuSK cells and non-transfected HEp-2 cells
Total incubation time 80 min.
Sample volume 10 µL serum
No. of determinations 60 (10 x 6)

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Current version of the instructions for use. The respective valid version for processing the test can be found in the product packaging.