8049 – Anti-MuSK IFA
Intended Purpose
The Anti-MuSK IFA is an immunofluorescence assay (IFA) for the qualitative and semi-quantitative determination of IgG antibodies in human serum against muscle specific tyrosine kinase (MuSK) on HEp-2 cells. The Anti-MuSK IFA is intended as an aid in the diagnosis of myasthenia gravis (MG) in conjunction with other clinical and laboratory findings. The immunoassay is designed for manual professional in vitro diagnostic use.
Diagnostic Relevance
Myasthenia gravis (MG), a neurological disease characterized by disturbed signal transmission between nerves and muscles, is an autoimmune disease, caused by autoantibodies directed against the striated muscle of the motor end plate. In most cases (ca 85%), acetylcholine receptor antibodies are detectable. Antibodies against muscle specific tyrosine kinase (MuSK) are also detectable in 1 – 10% of cases. In other cases, the so-called low affinity acetylcholine-receptor-antibodies or antibodies against the lipoprotein receptor-related protein (LRP4) are seen.
Product Specifications
Title | Anti-MuSK IFA |
Product code | 8049 |
Indication | Myasthenia gravis |
Description | Indirect immunofluorescence assay for the determination of IgG antibodies in human serum against muscle specific tyrosine kinase |
Format | Slides coated with transfected HEp-2 MuSK cells and non-transfected HEp-2 cells |
Total incubation time | 80 min. |
Sample volume | 10 µL serum |
No. of determinations | 60 (10 x 6) |
Free downloads
SDS [REF 8049][eng] SDS [REF 8049][deu] Flyer [REF 8049][Anti-MuSK IFA][eng] Flyer [REF 8049][Anti-MuSK IFA][deu]Restricted downloads - Password required
Current version of the instructions for use. The respective valid version for processing the test can be found in the product packaging.