6118, 6119 – Calprotectin Rapid

Highlights

• Use of highly specific monoclonal antibodies for rapid detection of calprotectin in human stool samples
• Supports diagnosis and monitoring of inflammatory bowel disease (IBD)
• Differentiates organic intestinal inflammation from functional disorders (e.g., IBS)
• Detects neutrophil-derived calprotectin, a key marker of intestinal inflammation
• Ready-to-use test cassettes with color-coded antibodies and sample buffer
• CE marked
• Manual, professional in vitro diagnostic use

Intended Use

The Calprotectin Rapid is a qualitative immunoassay for the determination of calprotectin in human stool samples. The test serves as a valuable aid in the diagnosis and monitoring of inflammatory bowel disease (IBD), complementing other clinical assessments and laboratory findings. It provides reliable results quickly and without the need for specialized instruments or invasive procedures. The immunoassay is designed for manual professional in vitro diagnostic use.

Diagnostic Relevance

Calprotectin is a heteromeric protein predominantly found in cytoplasmic neutrophil granulocytes, where it constitutes approximately 60% of soluble proteins. Upon neutrophil activation, calprotectin is released and becomes detectable in serum, other body fluids, and stool. Its presence in feces serves as a non-invasive marker of intestinal inflammation, reflecting neutrophil migration into the intestinal lumen.

Measurement of fecal calprotectin allows clinicians to differentiate between organic intestinal diseases, such as IBD, and functional gastrointestinal disorders, including irritable bowel syndrome (IBS). The assay is also valuable for monitoring disease activity over time, assessing patient response to therapy, predicting potential relapses, and detecting the presence of invasive intestinal pathogens. By providing early and reliable insight into intestinal inflammation, the Calprotectin Rapid supports timely clinical decision-making and effective management of gastrointestinal disorders, improving patient outcomes and reducing unnecessary invasive procedures.