Intended Purpose

The AKLIDES® ASMA is an immunofluorescence assay (IFA) for the qualitative determination of IgG antibodies in human serum against smooth muscle on tissue sections of rat stomach. The AKLIDES® ASMA is intended as an aid in the diagnosis of autoimmune liver diseases in conjunction with other clinical and laboratory findings. The immunoassay is designed for manual processing and automated imaging using the AKLIDES® or akiron® system. The immunoassay is designed for professional in vitro diagnostic use.

Diagnostic Relevance

Liver diseases such as acute and chronic hepatitis, primary biliary cirrhosis and other forms of liver cirrhosis are characterized by the presence of antibodies against smooth, unstriated muscles, hence a  means of diagnosis of ASMA. Additionally, ASMA supports the diagnosis of Systemic Lupus Erythematosus (SLE), infectious mononucleosis, breast and ovarian carcinoma and malignant melanomas. Detection of ASMA via indirect immunofluorescence assays using rat stomach is indicated by a fluorescence staining of the smooth muscle fibres in the muscularis mucosa, or in the tunica muscularis ventriculi, as well as by a fluorescence of the inter-glandular contractile fibers of the stomach mucosa.

Product Specifications

Product code 4119
Indication Autoimmune liver diseases
Description Indirect immunofluorescence assay for the determination of IgG antibodies in human serum against smooth muscle
Format Slides coated with cryostat tissue sections of rat stomach
Incubation time 60 min.
Sample volume 10 µL serum
No. of determinations 48 (12 x 4)

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  SDS [REF 4119][eng]   SDS [REF 4119][deu]

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Current version of the instructions for use. The respective valid version for processing the test can be found in the product packaging.