2080 – SELco® anti-TPO human

MEDIPAN SELco® anti-TPO human is an easy to use and reliable radioimmunoassay used for the quantitative and highly sensitive determination of thyroid peroxidase autoantibodies (anti-TPO) in human serum.

Thyroid peroxidase (TPO), a membrane-bound enzyme in the thyroid cell, plays an essential role in the synthesis of thyroid hormone, hence makes up one of the three thyroid antigens.

The presence of autoantibodies to thyroid antigens is a major indication of autoimmune thyroiditis. These autoantibodies target the thyroid glands and its hormone products thyroid hormones thyroxine (T4) and triiodothyronine (T3) and thyroid stimulating hormone (TSH) leading to hormonal dysfunction. Detection of such autoantibodies is an indication of chronic autoimmune thyroiditis, hence a marker for the differential diagnosis of hypothyroidism and the subclinical or latent type.

Detection of anti-TPO is also essential in the diagnosis of Grave’s disease, especially when the TSH Receptor Antibody value is negative, but the disease is clinically suspected. Besides Grave’s diseases, anti-TPO determination is also an indication of the exclusion of a co-existing thyroid autoimmune disease, as in euthyroid goiter.