2080 – SELco^® anti-TPO human

Highlights

• • Quantitative determination of antibodies against thyroid peroxidase (TPO)
• • Supports differential diagnosis of hypothyroidism and Graves’ disease
• • Detects autoantibodies in Hashimoto’s thyroiditis and other autoimmune thyroid diseases
• • Results expressed in IU/L
• • Excellent diagnostic sensitivity and specificity
• • High precision within the measurement range
• • CE marked
• • Automatable

Intended Purpose

The SELco^® anti-TPO human is a quantitative radioimmunoassay for the determination of antibodies against thyroid peroxidase (TPO) in human serum. The SELco^® anti-TPO human is intended as an aid in the diagnosis of thyroid diseases in conjunction with other clinical and laboratory findings. The immunoassay is designed for manual professional in vitro diagnostic use.

Diagnostic Relevance

Hashimoto’s thyroiditis is a polyendocrine autoimmune disease characterized by chronic inflammation of the thyroid gland. Antibodies, in particular against thyroid peroxidase (TPO) and thyroglobulin (Tg), lead to the destruction of thyroid tissue and thus to hypothyroidism in the long term, although phases of hyperthyroidism can also appear at the beginning of the disease.

Hashimoto’s thyroiditis is one of the most common autoimmune diseases and the most common cause of hypothyroidism. Women develop Hashimoto’s thyroiditis more often than men. Researchers have not fully clarified the exact causes, but genetic factors, stress, environmental influences, viral infections, and excessive iodine intake may contribute.

The symptoms of Hashimoto’s thyroiditis are diverse. At the disease onset, patients may experience hyperthyroidism, causing nervousness, sweating, overactivity, increased appetite, weight loss, tachycardia, arrhythmias, and hypertension. In the long term, however, the symptoms of an underactive thyroid gland predominate with fatigue, exhaustion, difficulty concentrating, depression, intolerance to cold, weight gain despite loss of appetite, constipation, menstrual disorders and bradycardia.

Clinicians usually diagnose Hashimoto’s thyroiditis based on clinical symptoms and confirm it by measuring antibodies against thyroid peroxidase (TPO) and thyroglobulin (Tg).They further assess thyroid function by measuring TSH, T3, and T4 levels. Additionally, clinicians can perform sonography, analyze thyroid tissue from a biopsy, or create a scintigram after administering radioactively labeled iodine.

Publications

• Farahati et al., (2012) Anti-TPO antibodies associated with absence of distant metastases in newly diagnosed breast cancer