6110 – Helicobacter Antigen Quick
The Helicobacter Antigen Quick is a qualitative immunoassay for the determination of Helicobacter pylori antigen in human stool specimens. The Helicobacter Antigen Quick intended as an aid in the diagnosis of infectious gastroenteritides in conjunction with other clinical and laboratory findings.
Helicobacter pylori (H. pylori), a common bacterial cause of peptic ulcers, can be effectively detected from stool (faecal) samples. Identified as the causative agent of peptic ulcers, gastritis, and gastric carcinoma, the spiral-shaped bacterium colonizes human stomach and duodenum. The acidic nature of the stomach is neutralized by the enzyme urease, which transforms urea into ammonia and carbon dioxide; this enables the bacteria to adapt to this environment. Occurring usually in childhood, over 90% of duodenal ulcers and 80% of gastric ulcers are caused by H. pylori. Advanced health care systems and therapies in developed countries have reduced the rate of infections; however, the reverse is the case in many developing countries.
Rapid immunochromatographic assays are widely used for the determination of specific antigens. If antigens are present in the patient´s sample, they are recognized by to color-coded antigen-specific antibodies. The generated immune complex migrates through the test strips by capillarity. The test strips are coated with additional antigen-specific antibodies. If antigens are present in the patient´s sample, the formed immune complex bind to the antibodies and colored bands become visible on the test strip. The signal intensity of the reaction product is proportional to the antigen concentration in the sample.
The immunoassay is designed for manual professional in vitro diagnostic use.
|Title||Helicobacter Antigen Quick|
|Indication||Helicobacter pylori infections|
|Description||Rapid immunochromatographic test for the detection of Helicobacter pylori antigen in human stool specimens|
|Format||Test strips coated with monoclonal antibodies against Helicobacter pylori|
|Incubation time||5 min.|
|Sample volume||5 mm sample|
|No. of determinations||25 (25 x 1)|