50381 – DotDiver Anti-Gangliosid IgG
The DotDiver Anti-Gangliosid IgG is a qualitative line immunoassay for the determination of IgG antibodies against gangliosides in human serum. The DotDiver Anti-Gangliosid IgG is intended as an aid in the diagnosis of autoimmune neuropathies in conjunction with other clinical and laboratory findings. The immunoassay is designed for semi-automated use with the DotDiver instrument. The immunoassay is designed for professional in vitro diagnostic use.
Clinical symptoms associated with inflammatory neuropathies of the peripheral nervous system range from mild signs like slight weariness, inexplicable indisposition to complicated cases such as functional deficiency like respiratory paralysis, cardiac arrest and neuromuscular disorders. Gangliosides, acid glycolipids containing a lipid (ceramide), oligosaccharide and sialic acid, are major components of cell membranes and found especially in the central and peripheral nervous system. Autoantibodies to gangliosides are detected in patients suffering from disorders of the peripheral nervous system.
Infection with Campylobacter jejuni, Cytomegalovirus, Epstein-Barr virus, Mycoplasma pneumoniae or Haemophilus influenza are risk factors for inflammatory neuropathies: Antibodies to ganglioside structures of these microorganisms may cross-react with gangliosides of the myelin sheath or neurofibre, leading to activation of inflammation processes with subsequent demyelination.
|Title||DotDiver Anti-Gangliosid IgG|
|Description||Line immunoassay for the qualitative determination of IgG antibodies against gangliosides in human serum|
|Format||Test strips coated with sulfatides, GM1, GM2, GM3, GM4, GD1a, GD1b, GD2, GD3, GT1a, GT1b and GQ1b|
|Total incubation time||95 min.|
|Sample volume||10 µL serum|
|No. of determinations||24 x 12|