4202 – CeliAK IgG LINE

Intended Use

The CeliAK IgG LINE is a qualitative line immunoassay for the determination of IgG antibodies against deamidated gliadin (d-gliadin) and tissue transglutaminase (tTG) in human serum. The CeliAK IgG LINE is intended as an aid in the diagnosis of celiac disease in conjunction with other clinical and laboratory findings. The immunoassay is designed for manual professional in vitro diagnostic use.


Diagnostic Relevance

Celiac disease or gluten-sensitivity is characterized by small intestinal damages leading to a so-called “flat” mucosa. Due to this extensive lesions, malabsorption occurs frequently accompanied with a depletion of key nutrients. The alcohol soluble fraction of gluten, gliadin, a substrate of tissue transglutaminase (tTG), represents a causative agent of celiac disease, by stimulating an inflammatory process in the small intestine.

Serological method of celiac disease diagnosis includes the detection of IgA and IgG antibodies to tissue transglutaminase and deamidated gliadin. IgA antibodies to tissue transglutaminase are considered to have the highest predictive value, thus patients suffering from IgA deficiency, a frequent concomitant disease in celiac patients, can be diagnosed using IgG type antibodies.

Product Specifications

Title CeliAK IgG LINE
Product code 4202
Indication Celiac disease
Description Line immunoassay for the qualitative determination of IgG antibodies against deamidated gliadin and tissue transglutaminase in human serum
Format Test strips coated with highly purified deamidated gliadin and tissue transglutaminase
Total incubation time 80 min.
Sample volume 10 µL serum
No. of determinations 20 x 2

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Current version of the instructions for use. The respective valid version for processing the test can be found in the product packaging.