4007 – ASCA IgG

Highlights

• Use of monoclonal antibodies against Saccharomyces cerevisiae (ASCA)
• Ready-to-use (exception: wash buffer), color- and barcoded reagents
• Quality assured handling in routine laboratories
• Short incubation times at room temperature (20–25 °C)
• Quantitative determination of IgG antibodies against Saccharomyces cerevisiae (ASCA)
• Excellent diagnostic sensitivity and specificity shortly after onset of the disease
• Supports differentiation of Crohn’s disease and ulcerative colitis
• High precision and linearity within the measurement range
• CE marked
• Fully automatable

Intended Purpose

The ASCA IgG is a quantitative enzyme-linked immunoassay for the determination of IgG antibodies against Saccharomyces cerevisiae in human serum. The ASCA IgG is intended as an aid in the diagnosis of Crohn’s disease and ulcerative colitis in conjunction with other clinical and laboratory findings. The immunoassay is designed for manual professional in vitro diagnostic use.

Diagnostic Relevance

Non-specific inflammatory bowel diseases, including Crohn’s disease (CD) (Enteritis regionalis) and ulcerative colitis (UC), involve chronic-remitting inflammatory processes in the intestine. Immunologic, genetic, infectious, and environmental factors contribute to the risk of developing these diseases. An important serological marker for the differential diagnosis of Crohn’s disease is the determination of IgA and IgG antibodies to Saccharomyces cerevisiae, which are highly prevalent (70 %) in patients with CD and atypical antineutrophile cytoplasmatic antigens (aANCA). Thus, ASCA, in combination with the detection of autoantibodies to atypical anti-neutrophil cytoplasmic antigens (aANCA), are a valid parameter for the differentiation of Crohn’s disease and ulcerative colitis.

Publications

• Rausch et al., (2025) First insights into microbial changes within an IBD Family Cohort study
• Bogdanos et al., (2012) Pancreatic-specific autoAbs to GP-2 mirror disease location and behaviour in younger patients with CD