3321 – D-Dimer Latex
The D-Dimer Latex is a qualitative and semi-quantitative immunoassay for the determination of circulating derivatives of cross-linked fibrin degradation products (XL-FDP, D-Dimer) in human plasma. The D-Dimer Latex is intended as an aid in the diagnosis of embolic or thrombotic events in conjunction with other clinical and laboratory findings.
Fibrinolysis, the catalytic breakdown of the fibrin in blood clots, is an important constituent of blood clotting disorder. The activation of thrombin, during blood clotting process, converts fibrinogen to fibrin, which polymerizes to form non-cross-linked soluble gel. Thrombin activated factor XIII converts the fibrin gel to cross-linked fibrin, leading to insoluble fibrin clot; this triggers the production of plasmin, the main clot-lysing enzyme. The fibrinolytic enzyme, plasmin, cleaves fibrinogen and fibrin into degradable products; only degradation product from cross-linked fibrin contain D-Dimer, hence this degradation product (XL-FDP) serve as a diagnostic marker of the blood clotting disorder, fibrinolysis.
The agglutination test is widely used for the determination of specific antigens. Latex particles are coated with antigen-specific antibodies. If specific antigens are present in the patient´s sample, they bind to the antibodies resulting in visible agglutination of the latex particles.
The immunoassay is designed for manual professional in vitro diagnostic use.
|Indication||Blood clotting disorders in embolic or thrombotic events|
|Description||Latex agglutination test for the qualitative and semi-quantitative detection of circulating derivatives of cross-linked fibrin degradation products (XL-FDP) in human plasma|
|Format||Agglutination slide with latex beads coated with monoclonal antibody against D-Dimer|
|Incubation time||3 min.|
|Sample volume||20 µL plasma|
|No. of determinations||100 (100 x 1)|