Title of the project
Automated determination of 8-OHdG (January 1, 2020 - June 30, 2022)
Reactive oxygen species (ROS) are continuously produced in living cells of aerobic organisms as part of physiological processes, metabolic and other biochemical reactions. These endogenously produced ROS and oxygen-free radicals have important physiological functions, but due to their reactive nature can cause oxidative damage to lipids, proteins and RNA/DNA. Exogenous factors such as stress, nutrition, sport, UV radiation, tobacco smoke, asbestos and carcinogenic substances can also produce ROS under various conditions. Under normal physiological conditions, a balance is maintained in all aerobic organisms between endogenous oxidants and numerous enzymatic and non-enzymatic/low molecular weight antioxidants. If an imbalance occurs, oxidants cause extensive damage to DNA, which in turn leads to ageing, malignant tumours and other degenerative diseases. In all living cells, damaged DNA is repaired enzymatically so that it regains its normal function, while defective DNA leads to mutations (base substitution, deletions and strand fragmentation) that can lead to carcinogenesis. Although oxidative damage to DNA leads to a broad range of sometimes very specific reaction products (bases and sugar modifications, covalent crosslinks, single- and double-stranded breaks), the interest focused mainly on nucleobase modifications and especially on the abundant 8-oxo-2-deoxyguanosine lesion, which is formed in vivo and can be quantitatively measured in cells after hydrolysis of the DNA to component bases.
Our participation in the following projects is funded by the European Regional Development Fund and the State of Brandenburg.
ESF (European Social Fund) projects:
Title of the project
Innovation Assistants for SMEs / small and medium-sized companies (2 July 2018 - 1 July 2019)
During this period, we had an employee supported by the Investitionsbank Brandenburg (ILB) through this development project. With this grant programme, the ILB supports assistants in the field of innovation.
The aim of the programme is to create a high level of training for employees, to facilitate access to scientific knowledge and to increase the innovation and competitiveness of SMEs in the State of Brandenburg by employing university and technical college graduates.
Our innovation assistant was specifically employed in the R&D department in the development of IVD diagnostics, especially in the development of LINE immunoassays for automatic processing.
Conclusion: This enables MEDIPAN GmbH to increase its economic performance and improve its market opportunities.
This project is funded by the Ministry of Labour, Social Affairs, Health, Women and Family from the European Social Fund and the State of Brandenburg.
Exhibitions and congresses
|MEDICA Düsseldorf 2020||Düsseldorf||16 - 19 November 2020|
|MEDLAB Middle East 2020||Dubai (VAE)||03 - 06 February 2020|
|MEDICA Düsseldorf 2019||Düsseldorf||18 - 21 November 2019|
|MEDLAB Middle East 2019||Dubai (VAE)||04 - 07 February 2019|
|MEDICA Düsseldorf 2018||Düsseldorf||12 - 16 November 2018|
|MEDLAB Middle East 2018||Dubai (VAE)||05 - 08 February 2018|
Our participation in the following congresses is funded by the European Regional Development Fund and the State of Brandenburg.
We thank all funding agencies for their confidence!